Postdoctoral studies in Biochemistry and Biophysics

At
the Department of Medical Biochemistry and Biophysics.

The department conducts a broad spectrum of biomedical research and education within medical biochemistry and biophysics. Presently our department consists of 11 research divisions with a total of approximately 300 employees.

Description of the research project/area of research
The group uses a system structural biology approach to study function and mechanism of enzymes that catalyze protein modifications (ADP-ribose transferases in particular) with emphasis on implications for cancer.

The focus of the current position will be on the biochemical characterization of ADP-ribose transferases. The group applies X-ray crystallography and a wide range of biophysical and biochemical techniques to study protein function. The laboratory has a strong track record in the use of high throughput technologies for protein production, crystallization and structure analysis. The laboratory is equipped with state-of-the-art instruments for protein chemistry, biophysics, crystallography, and high throughput technologies.

The project is initially for one year.

Qualifications of the applicant
A person is eligible for this position if he or she has obtained a PhD at a university outside Sweden, and is a non-Swedish citizen.

Applications are invited from researchers with a PhD degree or a foreign qualification deemed equivalent to a doctorate (PhD) in biophysics or biochemistry. The ideal candidate will have profound knowledge, both theoretical and practical, in protein biochemistry, as well as a proven experience in recombinant protein production. Preferably, the applicant has a record in structural and functional analysis of enzymes. Profound knowledge of protein biochemistry is required. Experience from assay development and enzyme inhibition studies is preferable. The candidate must have experience in writing scientific reports. Furthermore, the candidate must be a result-oriented problem-solver who requires minimal supervision. The candidate must be able to work within a team environment.

Hands-on experience with the following techniques will be considered an advantage:
- Enzymatic assays, including assay development
- Protein thermostability assays
- Biacore
- Isothermal Titration Calorimetry
- Analysis of protein-protein interactions
- X-ray crystallization
- in-silico methods for structural analysis of protein-ligand interactions

Information about research scholarship for postdoctoral studies
At Karolinska Institutet, scholarships may only be established for the education of the holder. Educational scholarships are restricted for postdoctoral studies lasting up to two years and exempted from Swedish income tax.

A scholarship for the pursuit of postdoctoral studies may be awarded for up to two years in the five years following the public defence (or equivalent) of a doctoral thesis. The scholarship amount is approved for up to six months at a time and is paid monthly.

Form of employment:
Fixed term employment with possibility to extension

Contact information
For further details about the research project and stipulations of the scholarship, please contact Dr. Herwig Schüler, PI Structural Biochemistry, +46 8 524 86840, herwig.schuler@ki.se

Union representatives:
SACO: Biborka Bereczky Veress, +46 70-173 85 75, biborka.bveress@ki.se
OFR: Anna Aleman, +46 8 524 866 07, anna.aleman@ki.se
SEKO: Gunnar Stenberg, +46 8 524 880 75, gunnar.stenberg@ki.se

Please send your application, marked with reference number 01432/2012, to reach us by no later than March 18 2012 to herwig.schuler@ki.se or by mail to Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Att Herwig Schüler, 171 77 Stockholm, Sweden. The following documents must be submitted with your application:

- Your full CV
- A one-page summary of previous research experience with an account of the applicant’s own contribution
- Contact details for two to three reference persons

source: http://ki.se/?l=en